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Human genetic variation in APOE (Apolipoprotein E) and MAPT gene (Microtubule Associated Protein Tau) significantly influences risk for Alzheimer’s disease (AD) and tauopathies including frontotemporal dementia (FTD) and progressive supranuclear palsy. APOE alleles (ε2, ε3, ε4) primarily affect glial

Telomeres protect our chromosomes and shorten with each cell division, a process tied to aging. Telomerase, the enzyme that replenishes these protective caps, is essential for stem cell function and cancer progression. Measuring telomerase activity is critical for understanding aging, cancer, and stem

We can now provide neurons and astrocytes with defined MAPT haplotypes, offering researchers access to cells selected by genetic background that is directly relevant to tau biology and neurodegenerative disease research.

What’s new?

• MAPT H1/H2 genotyping using SNP rs8070723
• H1c sub-haplotype identification

In CNS research, understanding disease mechanisms goes beyond tracking individual biomarkers—it requires insight into how entire biological pathways are regulated. From blood–brain barrier (BBB) integrity to glial activation and neuroinflammatory signaling, meaningful studies depend on high-resolution

APOE genotype–specific astrocyte biology has emerged as a central driver of Alzheimer’s disease and neurodegenerative risk. Recent studies demonstrate that the APOE4/4 genotype profoundly reshapes astrocyte function across multiple pathways, including lipid metabolism, neuroinflammatory signaling, and

Evaluate cAMP-dependent signaling with ScienCell’s CRE/CREB Dual Reporter Vector (CREVR, Cat. No. VT004). CREB regulates gene expression in response to cAMP/PKA, calcium, and other signaling pathways, controlling metabolism, neuronal activity, and stress responses. Accurate measurement of CRE activity

Apolipoprotein E (ApoE) is a key regulator of lipid transport and cholesterol homeostasis, and genetic differences in the APOE gene significantly influence susceptibility to neurodegenerative and cardiovascular diseases. Understanding a sample’s APOE genotype provides essential biological context across

Cells constantly sense and adapt to their environment. Nutrients, stress, and signaling molecules can switch genes on or off, and tracking these events is crucial for understanding cell behavior, disease mechanisms, and therapeutic responses. But how can we observe these molecular conversations in real

Seeing Gene Activity in Real Time

Cells constantly respond to changes in their environment—switching genes on and off in response to stress, nutrients, or signaling molecules. Studying how and when these genes are activated is essential for understanding cellular communication, disease progression, and

The Wnt pathway plays a central role in cell signaling, development, and disease, yet studying it often poses technical challenges. Its complexity stems from a tightly regulated network of proteins and receptors that drive processes such as stem cell renewal, tissue regeneration, and cancer progression.