Cell Based Assays

Understanding the Impact of Genetic Variation on Endothelial Cell Function 

 
Endothelial dysfunction is a hallmark of cardiovascular disease and is closely associated with hypertension, diabetes, vascular aging, inflammation, and oxidative stress. Because endothelial nitric oxide synthase (eNOS), encoded

Cellular oxidative stress arises from an imbalance between reactive oxygen/nitrogen species (ROS/RNS) and antioxidant defenses, contributing to disease progression and cellular dysfunction. Quantitative assessment of redox status is therefore essential for understanding cellular responses and evaluating

Telomeres protect our chromosomes and shorten with each cell division, a process tied to aging. Telomerase, the enzyme that replenishes these protective caps, is essential for stem cell function and cancer progression. Measuring telomerase activity is critical for understanding aging, cancer, and stem

Apolipoprotein E (ApoE) is a key regulator of lipid transport and cholesterol homeostasis, and genetic differences in the APOE gene significantly influence susceptibility to neurodegenerative and cardiovascular diseases. Understanding a sample’s APOE genotype provides essential biological context across

Seeing Gene Activity in Real Time

Cells constantly respond to changes in their environment—switching genes on and off in response to stress, nutrients, or signaling molecules. Studying how and when these genes are activated is essential for understanding cellular communication, disease progression, and

Several key metabolites play crucial roles in cellular bioenergetic homeostasis. ScienCell has developed sensitive assays to accurately quantify L-lactate, glucose, glutamate, and pyruvate. 

L-Lactate is a key intermediate in glucose metabolism. Under hypoxic conditions, lactate dehydrogenase

Advance Your Telomere Research Using ScienCell’s Absolute Telomere Length Quantification qPCR Kits!
 

Understanding Telomeres and Their Role in Genomic Stability

Telomeres are nucleoprotein structures that cap chromosome ends, protecting them from degradation and ensuring genomic stability. Each cell

Telomere “caps” are located at the ends of all chromosomes, including those of the immune system’s T-lymphocytes (T cells), and become shorter with every cell division. Once these chromosomes reach a point where the telomere is too short to provide adequate protection, division ceases and the cell proceeds

SARS-CoV-2 is the seventh known coronavirus that causes the human disease known as COVID-19. The virus can grow in cells lining the conducting airways and in alveolar epithelial cells. First, the virus generally enters the body through the nose or mouth. From there, the virus travels down into the alveoli

Traditional 2D cultures have been used widely over the past decades to study cell biology, molecular biology and conduct translation research such as drug discovery. Cells in 2D culture, however, are forced to adopt a planar morphology and maintain cellular interactions only in lateral directions, altering