APOE genotype–specific astrocyte biology has emerged as a central driver of Alzheimer’s disease and neurodegenerative risk. Recent studies demonstrate that the APOE4/4 genotype profoundly reshapes astrocyte function across multiple pathways, including lipid metabolism, neuroinflammatory signaling, and
Apolipoprotein E (ApoE) is a key regulator of lipid transport and cholesterol homeostasis, and genetic differences in the APOE gene significantly influence susceptibility to neurodegenerative and cardiovascular diseases. Understanding a sample’s APOE genotype provides essential biological context across
Alzheimer’s disease (AD) affects almost 44 million people worldwide. The disease typically begins with memory difficulties followed by trouble thinking, reasoning and processing emotions. The cause of AD is not well understood, but there appear to be two forms: 90% of patients have a late-onset sporadic
