ApoE

Human genetic variation in APOE (Apolipoprotein E) and MAPT gene (Microtubule Associated Protein Tau) significantly influences risk for Alzheimer’s disease (AD) and tauopathies including frontotemporal dementia (FTD) and progressive supranuclear palsy. APOE alleles (ε2, ε3, ε4) primarily affect glial

We can now provide neurons and astrocytes with defined MAPT haplotypes, offering researchers access to cells selected by genetic background that is directly relevant to tau biology and neurodegenerative disease research.

What’s new?

• MAPT H1/H2 genotyping using SNP rs8070723
• H1c sub-haplotype identification